Fluticasone Propionate belongs to a class of drugs known as corticosteroids, specifically glucocorticoids, which are hormones that predominantly affect the metabolism of carbohydrates and, to a lesser extent, fat and protein. It is used to treat asthma, allergic rhinitis, nasal polyps, various skin disorders and Crohn’s disease and ulcerative colitis. It is also used to treat eosinophilic esophagitis.
Asthma: Fluticasone is used by powder or aerosol inhalation for the prophylaxis of asthma. Typical initial doses in the UK range from 100 to 250 micrograms twice daily in mild asthma up to 1 mg twice daily in severe asthma, adjusted according to response. Children over four years of age may be given initial doses of 50 to 100 micrograms twice daily, increased to 200 micrograms twice daily if necessary. The drug may also be given via a nebuliser in severe chronic asthma. Usual adult doses are 0.5 to 2 mg twice daily. Children aged four to sixteen years may be given 1 mg twice daily.
Allergic rhinitis: Nasal spray preparation of fluticasone propionate is used in the prophylaxis and treatment of allergic rhinitis. The usual dose is 100 micrograms into each nostril once daily, increased if necessary to 100 micrograms into each nostril twice daily. Children aged 4-11 years may be given half these doses.
Nasal polyps: Fluticasone propionate nasal drops are used in the treatment of nasal polyps. 200 micrograms should be instilled into each nostril once or twice daily for at least four to six weeks.
Other: Creams and ointments containing 0.05% and 0.005% Fluticasone propionate, respectively, are available and applied topically in the treatment of various skin disorders. It can be given orally in the treatment of Crohn’s disease and ulcerative colitis. Some benefit was also reported in coeliac disease. The dose is 5 mg four times daily but some consider higher doses necessary.
The dose of fluticasone propionate will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of fluticasone propionate. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For nasal spray dosage form (For allergies):
Adults: 2 sprays in each nostril once a day, or 1 spray in each nostril two times a day. Later, your doctor may decrease your dose to 1 spray in each nostril once a day.
Children 4 years of age and older (including teenagers): 1 spray in each nostril once a day. Your doctor may need to increase the dose in some children, up to 2 sprays in each nostril once a day, or 1 spray in each nostril twice a day.
Children younger than 4 years of age: Use and dose must be determined by your doctor.
If taken correctly, the nasal spray and oral inhaler formulation have less corticosteroid side effects than the tablet formulation because they limit systemic (blood) absorption. However, if the spray or inhaler is used at higher than recommended doses or with other corticosteroids, serious side effects can occur. These systemic corticosteroid side effects include weakened immune system, increased risk of systemic infections, osteoporosis, and elevated pressure in the eyes.
Nasal spray: Common side effects may include nasal irritation, headache, nausea, vomiting, diarrhea, nosebleed, and cough. Rare side effects include painful white patches in nose or throat, sore throat, bruising (erythema nodosum), vision problems, swelling of face or neck, and difficulty breathing or swallowing.
Oral inhaler: Common side effects may include upper respiratory tract infection, throat irritation, thrush, cough, and headache. Rare side effects include bruising, swelling of the face/neck, depression, tiredness, and shortness of breath.