Rosuvastatin 20 mg Tablet | Formulation & Manufacturing Process

Rosuvastatin is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. It is recommended to be used together with dietary changes, exercise, and weight loss. It is taken orally (by mouth).

Rosuvastatin was patented in 1991, and approved for medical use in the United States in 2003. It is available as a generic medication. In 2020, it was the seventeenth most commonly prescribed medication in the United States, with more than 29 million prescriptions.

There are several dosage forms and strengths available with Rosuvastatin. One of the most common of which is Rosuvastatin 20 mg Tablet.

Each film-coated tablet contains Rosuvastatin 20 mg as Rosuvastatin Calcium BP. The formulation & manufacturing process of Rosuvastatin 20 mg Tablet is as below:


Each tablet contains:

Active Ingredient
1Rosuvastatin CalciumBP20.774 mg
(equivalent to
Rosuvastatin 20 mg)
2Microcrystalline Cellulose 101BP83.865 mg 
3Sodium Starch GlycolateBP7.000 mg 
4Colloidal Anhydrous SilicaBP3.000 mg 
5Magnesium StearateBP2.004 mg 
6Lactose MonohydrateBP63.770 mg 
7Polyvinylpyrrolidone K-30BP2.394 mg 
Coating Materials
8Hydroxypropyl MethylcelluloseBP3.498 mg 
9Polyethylene Glycol 6000BP0.756 mg 
10Propylene GlycolBP1.002 mg 
11Purified TalcBP0.7380 mg 
12Titanium DioxideBP0.7560 mg 
13* Carnauba WaxBP0.102 mg 
14* ChloroformBP1.338 mg 
15* Purified WaterBP46.670 mg 
* Will not appear in the final product
** The formulation varies from Man to Man, Machine to Machine, Method to Method, and Materials to Materials.

Manufacturing Process:

The process consists of sieving the active ingredient & excipients through the Vibration Shifter and granules preparation by rapid mixture/granulator & blending that is followed by a Drum Blender. Tablet will be compressed by the tablet compression machine and coating will be carried out by Auto coater. Tablets will be blistered by the Blister machine.

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