Pharma Jogot
Povidone Iodine, also known as iodopovidone, is an antiseptic used for skin disinfection before and after surgery. It may be used both to disinfect the hands of healthcare providers and the skin of the person they are caring for. It may also be used for minor wounds. It may be applied to the skin as a liquid or a powder.
Povidone Iodine came into commercial use in 1955. It is on the World Health Organization’s List of Essential Medicines. Povidone Iodine is available over the counter.
There are several dosage forms and strengths available with Povidone Iodine. One of the most common of which is Povidone Iodine 6% Cream.
Each gram of cream contains Povidone Iodine USP 60 mg. The formulation & manufacturing process of Povidone Iodine 6% Cream is as below:
Formulation:
Each gram of cream contains:
| SN | COMPOSITION | SPECIFICATION | QUANTITY | FUNCTION |
| Active Ingredient(s): | ||||
| 1 | Povidone Iodine | USP | 60.000 mg | |
| Excipient(s): | ||||
| 2 | Polyethylene Glycol 4000 | USP | 210.000 mg | |
| 3 | Glycerin | BP | 300.000 mg | |
| 4 | Propylene Glycol | BP | 410.000 mg | |
| 5 | Purified Water | BP | 20.000 mg | |
| ** The formulation varies from Man to Man, Machine to Machine, Method to Method, and Materials to Materials. | ||||
Manufacturing Process:
- Active ingredients and excipients are weighed accurately.
- Add Povidone Iodine in Purified water and heat up to 60ºC under stirring conditions until the solution becomes clear.
- Add Propylene Glycol, Glycerin, Polyethylene Glycol 4000 and heat up to 80ºC under stirring conditions until melt and clear.
- Add the content of step 2 to step 3 maintaining the temperature at 60ºC under stirring conditions let the temperature be normal under stirring conditions and commence for the QC sample.